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DTSTART:20241115T170000Z
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SUMMARY:CANCELLED: Biology Lecture Series: Dry Preservation of Red Blood Cells and Beyond
DESCRIPTION:Due to unforeseen circumstances\, we will have to reschedule 
 the Biological Sciences seminar scheduled for tomorrow\, Friday November 
 15th.\n\nRegistrants will be informed of the new seminar date as soon as it 
 is scheduled.  If you have any additional questions\, please contact Lisa 
 Ferrara or Emily Schmitt Lavin.\n\nTransfusable RBCs have a limited shelf 
 life of 42 days after donation due to detrimental storage effects on their 
 physiological properties\, and the lack of transfusable RBC units is a 
 leading cause of preventable warfighter deaths in far-forward military 
 settings and a logistic challenge for healthcare in remote locations. 
 Methods to increase the shelf life of transfusible units in a desiccated 
 state would allow for treatment at the point of injury\, but viable 
 freeze-dried RBCs do not exist. The failure to develop dry-preservation 
 protocols for RBCs is surprising\, considering some animals have evolved 
 the propensity to survive fully desiccated for months to decades 
 (anhydrobiotes) and resume life after exposure to water. For example\, the 
 encysted embryos of the brine shrimp Artemia franciscana accumulate high 
 concentrations of the non-reducing sugar trehalose and intrinsically 
 disordered polypeptides (e.g.\, LEAPs) before the onset of water stress to 
 survive the removal of virtually all cellular water (anhydrobiotes). This 
 seminar will introduce molecular mechanisms anhydrobiotic animals employ to 
 survive desiccation and highlight the challenges of applying biomimetic 
 approaches to engineer desiccation tolerance into RBCs. Furthermore\, 
 strategies for translating lab bench-based innovations into real-world 
 solutions will be discussed.\n\nDisclosure: Michael Menze has financial 
 interests in the intellectual property of this research and founded 
 DesiCorp\, LLC\, to commercialize invented technology.\n\n \n\nAbout the 
 Presenter\n\nAs an undergraduate student of Biology\, Dr. Michael A. Menze 
 was intrigued by the molecular mechanisms that allow animals to survive 
 harsh environmental insults. He earned his doctoral degree in Physiology 
 and Biophysics\, pursuing a collaborative project between the Institute for 
 Zoophysiology at the University of Duesseldorf and the Institute for 
 Molecular Biophysics at the University of Mainz\, Germany. During his 
 doctoral training\, he elucidated the role of allosteric regulation of 
 respiratory pigments in the hypoxia tolerance of crustaceans. He continued 
 his work on stress tolerance of animals during his postdoctoral work at 
 Louisiana State University and Harvard Medical School. During this time\, 
 he started focusing on animals that can survive in a desiccated state and 
 reanimate after exposure to water (anhydrobiosis). He primarily focused on 
 the mechanisms of water-stress tolerance in invertebrates promoted by 
 compatible organic osmolytes and proteaceous protectants to evaluate their 
 potential for the biostabilization of clinically relevant cells and 
 biologics.\n\nAfter his postdoctoral training\, he taught at Easter 
 Illinois University in Charleston\, IL\, before joining the University of 
 Louisville in Louisville\, KY. Over the past several years at UofL\, he 
 served the Biology Department as Professor and Assistant Chair before being 
 appointed Associate Dean for Research and Innovation in the College of Arts 
 and Sciences. A variety of agencies\, including the Department of Defense 
 (DOD)\, the National Institutes of Health (NIH)\, the National Science 
 Foundation (NSF)\, and the National Aeronautics and Space Administration 
 (NASA)\, provided funding for his work. Dr. Menze has published over 60 
 peer-reviewed journal articles and book chapters\, including in the 
 Proceedings of the National Academy of Sciences\, the Annual Review of 
 Physiology\, and the Journal of Biological Chemistry\, and part of his work 
 has led to patented intellectual property.\n\nDr. Menze continues to 
 investigate the molecular basis of animal anhydrobiosis to develop 
 biomimetic approaches to improve the long-term preservation of biologics. 
 He uses various techniques to elucidate and utilize the biochemical 
 strategies observed in stress-tolerant animals to address societal 
 challenges. Current projects include the dry preservation of red blood 
 cells for transfusion in austere environments\, stabilizing 
 biomedical-relevant model cell lines at room temperature\, and the 
 long-term storage of genetic model organisms such as the fruit fly 
 Drosophila. Recent focus areas also include the role of protein intrinsic 
 disorder in liquid-liquid phase separations and the formation of 
 biomolecular condensates as a prerequisite for desiccation tolerance in 
 animals.
LOCATION:NSU Broward Center of Innovation | Alan B. Levan
ORGANIZER;CN="Lisa Ferrara":MAILTO:lferrara@nova.edu
CATEGORIES: In-Person
CONTACT;CN="Lisa Ferrara":MAILTO:lferrara@nova.edu
STATUS:CONFIRMED
UID:LibCal-13091361
URL:https://nova.libcal.com/event/13091361
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